Actos Side Effects

Since Actos (pioglitazone) was approved in 1999 for the treatment of type 2 diabetes, the Food and Drug Administration has issued three alerts about significant side effects that warranted more urgent warnings on product inserts:

June 15, 2011 – Actos-containing drugs are associated with a 40 percent increased bladder cancer risk (see FDA warning) among patients taking the drugs for more than 12 months and patients taking the highest cumulative doses.

March 9, 2009 – Drugs containing Actos are associated with an increased risk of bone fractures in women, particularly in the bones of the hands, feet and upper arms.

August 14, 2007 – Actos and the other diabetes drugs in its class are associated with heart failure, particularly among patients older than 64 and patients who also take insulin to control their high blood sugar.

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Other side effects include liver failure or damage, swelling in the macula behind the eye, swollen hands, legs and feet, hypoglycemia when used with insulin, anemia and ovulation.

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